Title : Positive and negative regulation of insulin action by genistein in the endothelium.

Pub. Date : 2013 Jan

PMID : 22901685






1 Functional Relationships(s)
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1 Genistein inhibited insulin-stimulated tyrosine phosphorylation of insulin receptor substrate-1 (IRS-1) and attenuated downstream Akt and endothelial nitric oxide synthase (eNOS) phosphorylation, leading to a decreased nitric oxide (NO) production in endothelial cells. Tyrosine insulin receptor substrate 1 Rattus norvegicus