Title : Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome.

Pub. Date : 2012 Aug 28

PMID : 22891354






5 Functional Relationships(s)
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1 Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome. Fingolimod Hydrochloride brain derived neurotrophic factor Mus musculus
2 In cultured neurons, fingolimod increases BDNF levels and counteracts NMDA-induced neuronal death in a BDNF-dependent manner. Fingolimod Hydrochloride brain derived neurotrophic factor Mus musculus
3 In cultured neurons, fingolimod increases BDNF levels and counteracts NMDA-induced neuronal death in a BDNF-dependent manner. Fingolimod Hydrochloride brain derived neurotrophic factor Mus musculus
4 Ongoing synaptic activity and MAPK signaling is required for fingolimod-induced BDNF increase, a pathway that can also be activated in vivo by systemic fingolimod administration. Fingolimod Hydrochloride brain derived neurotrophic factor Mus musculus
5 Ongoing synaptic activity and MAPK signaling is required for fingolimod-induced BDNF increase, a pathway that can also be activated in vivo by systemic fingolimod administration. Fingolimod Hydrochloride brain derived neurotrophic factor Mus musculus