Title : 18β-glycyrrhetinic acid potentiates Hsp90 inhibition-induced apoptosis in human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathway.

Pub. Date : 2012 Nov

PMID : 22865487






3 Functional Relationships(s)
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1 18beta-glycyrrhetinic acid potentiates Hsp90 inhibition-induced apoptosis in human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathway. 18alpha-glycyrrhetinic acid heat shock protein 90 alpha family class A member 1 Homo sapiens
2 18beta-Glycyrrhetinic acid enhanced Hsp90 inhibitor-induced apoptosis-related protein activation, nuclear damage, and cell death. 18alpha-glycyrrhetinic acid heat shock protein 90 alpha family class A member 1 Homo sapiens
3 The results suggest that 18beta-glycyrrhetinic acid may potentiate the Hsp90 inhibition-induced apoptosis in ovarian carcinoma cell lines via the activation of the caspase-8- and Bid-dependent pathways and the mitochondria-mediated cell death pathway, leading to activation of caspases. 18alpha-glycyrrhetinic acid heat shock protein 90 alpha family class A member 1 Homo sapiens