Pub. Date : 2012 Nov
PMID : 22865487
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 18beta-glycyrrhetinic acid potentiates Hsp90 inhibition-induced apoptosis in human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathway. | 18alpha-glycyrrhetinic acid | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 2 | 18beta-Glycyrrhetinic acid enhanced Hsp90 inhibitor-induced apoptosis-related protein activation, nuclear damage, and cell death. | 18alpha-glycyrrhetinic acid | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 3 | The results suggest that 18beta-glycyrrhetinic acid may potentiate the Hsp90 inhibition-induced apoptosis in ovarian carcinoma cell lines via the activation of the caspase-8- and Bid-dependent pathways and the mitochondria-mediated cell death pathway, leading to activation of caspases. | 18alpha-glycyrrhetinic acid | heat shock protein 90 alpha family class A member 1 | Homo sapiens |