Title : Biochemical mapping of human NEIL1 DNA glycosylase and AP lyase activities.

Pub. Date : 2012 Sep 1

PMID : 22858590






1 Functional Relationships(s)
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1 Single-turnover kinetics of NEIL1 revealed that removal of 5-hydroxycytosine (5-OHC) and 5-hydroxyuracil (5-OHU) is ~25 and ~10-fold faster in duplex DNA compared to single-stranded DNA, respectively, and also faster than removal of dihydrothymine (DHT) and dihydrouracil (DHU), both in double-stranded and single-stranded DNA. 5-ohc nei like DNA glycosylase 1 Homo sapiens