Title : Liver X receptor β and peroxisome proliferator-activated receptor δ regulate cholesterol transport in murine cholangiocytes.

Pub. Date : 2012 Dec

PMID : 22729460






3 Functional Relationships(s)
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Protein Name
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1 Liver X receptor beta and peroxisome proliferator-activated receptor delta regulate cholesterol transport in murine cholangiocytes. Cholesterol peroxisome proliferator activator receptor delta Mus musculus
2 Activation of LXRbeta and/or PPARdelta in cholangiocytes induces ATP-binding cassette cholesterol transporter A1 (ABCA1) and increases cholesterol export at the basolateral compartment in polarized cultured cholangiocytes. Cholesterol peroxisome proliferator activator receptor delta Mus musculus
3 In addition, PPARdelta induces Niemann-Pick C1-like L1 (NPC1L1), which imports cholesterol into cholangiocytes and is expressed on the apical cholangiocyte membrane via specific interaction with a peroxisome proliferator-activated response element (PPRE) within the NPC1L1 promoter. Cholesterol peroxisome proliferator activator receptor delta Mus musculus