Title : Mice lacking AMP-activated protein kinase α1 catalytic subunit have increased bone remodelling and modified skeletal responses to hormonal challenges induced by ovariectomy and intermittent PTH treatment.

Pub. Date : 2012 Sep

PMID : 22700192






2 Functional Relationships(s)
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1 By contrast, non-ovariectomised Ampkalpha1(-/-) mice responded better to iPTH treatment than non-ovariectomised Ampkalpha1(+)(/)(+) mice. ipth protein kinase, AMP-activated, alpha 1 catalytic subunit Mus musculus
2 Overall, these data demonstrate that Ampkalpha1(-/-) mice are less affected by changes in bone turnover induced by OVX but respond better to the anabolic challenge induced by iPTH. ipth protein kinase, AMP-activated, alpha 1 catalytic subunit Mus musculus