Pub. Date : 2012 Aug
PMID : 22581300
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Promoter methylation of RASSF1A modulates the effect of the microtubule-targeting agent docetaxel in breast cancer. | Docetaxel | Ras association domain family member 1 | Homo sapiens |
| 2 | Therefore, the potential associations of RASSF1A hypermethylation and response to docetaxel-based chemotherapy were evaluated, and the underlying mechanism was studied. | Docetaxel | Ras association domain family member 1 | Homo sapiens |
| 3 | Finally, in vitro studies showed that RASSF1A had cooperative activity in suppression of cancer cell growth and proliferation by enhancing docetaxel-induced cell cycle arrest. | Docetaxel | Ras association domain family member 1 | Homo sapiens |
| 4 | Our results suggest that hypermethylated RASSF1A is an important modulating factor for the efficacy of docetaxel-based chemotherapy in breast cancer. | Docetaxel | Ras association domain family member 1 | Homo sapiens |