Pub. Date : 2012
PMID : 22532801
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We found that the energy regulator AMPK, which potently inhibits fatty acid synthesis, restricts infection of the Bunyavirus, Rift Valley Fever Virus (RVFV), an important re-emerging arthropod-borne human pathogen for which there are no effective vaccines or therapeutics. | Fatty Acids | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |
| 2 | Furthermore, we found that AMPK is activated during RVFV infection, leading to the phosphorylation and inhibition of acetyl-CoA carboxylase, the first rate-limiting enzyme in fatty acid synthesis. | Fatty Acids | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |
| 3 | This restriction could be bypassed by treatment with the fatty acid palmitate, demonstrating that AMPK restricts RVFV infection through its inhibition of fatty acid biosynthesis. | Fatty Acids | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |
| 4 | Therefore, AMPK is an important component of the cell intrinsic immune response that restricts infection through a novel mechanism involving the inhibition of fatty acid metabolism. | Fatty Acids | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |