Title : Prostaglandin E2 modulates IL-8 expression through formation of a multiprotein enhanceosome in human colonic epithelial cells.

Pub. Date : 2012 Apr

PMID : 22531917






3 Functional Relationships(s)
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1 Prostaglandin E2 modulates IL-8 expression through formation of a multiprotein enhanceosome in human colonic epithelial cells. Dinoprostone C-X-C motif chemokine ligand 8 Homo sapiens
2 PGE(2) binding and coupling through EP2/4 receptor subtypes on colonic epithelial cells stimulates cyclic adenosine monophosphate (cAMP) and IL-8 production. Dinoprostone C-X-C motif chemokine ligand 8 Homo sapiens
3 These data unravel the mechanisms by which expression of IL-8 is controlled by different signalling pathways that are activated by PGE(2) but acting through different EP receptors. Dinoprostone C-X-C motif chemokine ligand 8 Homo sapiens