Title : Nicotine-induced changes of brain β-endorphin.

Pub. Date : 2012 Jun

PMID : 22483037






8 Functional Relationships(s)
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1 Nicotine-induced changes of brain beta-endorphin. Nicotine proopiomelanocortin Homo sapiens
2 Although behavioral studies have shown that beta-endorphin contributes to the rewarding and emotional effects of nicotine, whether the drug alters the function of brain endorphinergic neurons is not fully explored. Nicotine proopiomelanocortin Homo sapiens
3 These studies investigated the effect of acute, 1mg/kg, sc, and chronic, daily injection of 1mg/kg, sc, for 14 days, administration of free base nicotine on brain beta-endorphin and its precursor proopiomelanocortin (POMC). Nicotine proopiomelanocortin Homo sapiens
4 Acute and chronic treatment with nicotine decreased beta-endorphin content in hypothalamus, the principal site of beta-endorphin producing neurons in the brain, and in the endorphinergic terminal fields in striatum and hippocampus. Nicotine proopiomelanocortin Homo sapiens
5 Acute and chronic treatment with nicotine decreased beta-endorphin content in hypothalamus, the principal site of beta-endorphin producing neurons in the brain, and in the endorphinergic terminal fields in striatum and hippocampus. Nicotine proopiomelanocortin Homo sapiens
6 The acute effect of nicotine on beta-endorphin was reversed by the nicotinic antagonist mecamylamine and the dopamine antagonist haloperidol, indicating pharmacological specificity and involvement of dopamine D2-like receptors. Nicotine proopiomelanocortin Homo sapiens
7 POMC mRNA in hypothalamus and prefrontal cortex was unchanged following acute nicotine, but it decreased moderately with chronic treatment. Nicotine proopiomelanocortin Homo sapiens
8 Taken together, these results could be interpreted to indicate that nicotine alters the synthesis and release of beta-endorphin in the limbic brain in vivo. Nicotine proopiomelanocortin Homo sapiens