Title : Intestinal transport of pure diester-type alkaloids from an aconite extract across the Caco-2 cell monolayer model.

Pub. Date : 2012 May

PMID : 22411726






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Digoxin, as a P-glycoprotein (P-gp) substrate, was substantially effluxed in the basolateral to apical direction but inhibited by the three alkaloids. Alkaloids ATP binding cassette subfamily B member 1 Homo sapiens
2 Digoxin, as a P-glycoprotein (P-gp) substrate, was substantially effluxed in the basolateral to apical direction but inhibited by the three alkaloids. Alkaloids ATP binding cassette subfamily B member 1 Homo sapiens
3 These observations indicated that the three alkaloids may not only be P-gp inhibitors but also its substrates; they interact with each other and can potentially enhance their own bioavailability when taken concomitantly. Alkaloids ATP binding cassette subfamily B member 1 Homo sapiens