Title : The N-terminal region of acyl-CoA synthetase 3 is essential for both the localization on lipid droplets and the function in fatty acid uptake.

Pub. Date : 2012 May

PMID : 22357706






5 Functional Relationships(s)
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1 Fluorescence microscopy showed that ACSL3 is localized to the endoplasmic reticulum (ER) and LDs, with the distribution dependent on the cell type and the supply of fatty acids. Fatty Acids acyl-CoA synthetase long chain family member 3 Homo sapiens
2 ACSL3 was effectively translocated from the ER to nascent LDs when neutral lipid synthesis was stimulated by the external addition of fatty acids. Fatty Acids acyl-CoA synthetase long chain family member 3 Homo sapiens
3 Cellular fatty acid uptake was increased by overexpression and reduced by RNA interference of ACSL3. Fatty Acids acyl-CoA synthetase long chain family member 3 Homo sapiens
4 ACSL3 not only esterifies fatty acids with CoA but is also involved in the cellular uptake of fatty acids, presumably indirectly by metabolic trapping. Fatty Acids acyl-CoA synthetase long chain family member 3 Homo sapiens
5 ACSL3 not only esterifies fatty acids with CoA but is also involved in the cellular uptake of fatty acids, presumably indirectly by metabolic trapping. Fatty Acids acyl-CoA synthetase long chain family member 3 Homo sapiens