Title : Akt inhibitors MK-2206 and nelfinavir overcome mTOR inhibitor resistance in diffuse large B-cell lymphoma.

Pub. Date : 2012 May 1

PMID : 22338016






2 Functional Relationships(s)
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1 Akt inhibitors MK-2206 and nelfinavir overcome mTOR inhibitor resistance in diffuse large B-cell lymphoma. Nelfinavir mechanistic target of rapamycin kinase Homo sapiens
2 Nelfinavir and MK-2206, chosen for their Akt-inhibitory properties, yielded synergistic inhibition of cell viability in combination with rapamycin in DLBCL cell lines, and potently inhibited phosphorylation of Akt and downstream targets of activated mTOR. Nelfinavir mechanistic target of rapamycin kinase Homo sapiens