Title : Puerarin attenuates endothelial insulin resistance through inhibition of inflammatory response in an IKK╬▓/IRS-1-dependent manner.

Pub. Date : 2012 May

PMID : 22314193






2 Functional Relationships(s)
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Protein Name
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1 Puerarin attenuated PA-induced phosphorylation of insulin receptor substrate-1 (IRS-1) at S307 and effectively ameliorated insulin-mediated tyrosine phosphorylation of IRS-1. Tyrosine insulin receptor substrate 1 Rattus norvegicus
2 The beneficial modification of serine/tyrosine phosphorylation of IRS-1 restored downstream Akt/eNOS activation, and thereby increased insulin-mediated NO production. Tyrosine insulin receptor substrate 1 Rattus norvegicus