Title : Nocodazole increases the ERK activity to enhance MKP-1expression which inhibits p38 activation induced by TNF-α.

Pub. Date : 2012 May

PMID : 22294037






5 Functional Relationships(s)
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1 Nocodazole increases the ERK activity to enhance MKP-1expression which inhibits p38 activation induced by TNF-alpha. Nocodazole mitogen-activated protein kinase 14 Homo sapiens
2 In this article, we report that nocodazole, a widely used microtubule-interfering agent, antagonized UV- or TNF-alpha-induced p38 activation, even though this drug by itself weakly activated p38. Nocodazole mitogen-activated protein kinase 14 Homo sapiens
3 The RNA synthesis inhibitor actinomycin D, but not p38-specific inhibitor SB203580, reversed the inhibitory effect of nocodazole on TNF-alpha-induced p38 activation. Nocodazole mitogen-activated protein kinase 14 Homo sapiens
4 The inhibition by nocodazole of TNF-alpha-induced p38 activation was abolished by ERK-specific inhibitor U0126. Nocodazole mitogen-activated protein kinase 14 Homo sapiens
5 Thus, nocodazole increases the ERK activity to enhance MKP-1 expression which inhibits p38 activation induced by TNF-alpha. Nocodazole mitogen-activated protein kinase 14 Homo sapiens