Pub. Date : 2012 Apr 1
PMID : 22275756
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Muscle-derived expression of the chemokine CXCL1 attenuates diet-induced obesity and improves fatty acid oxidation in the muscle. | Fatty Acids | chemokine (C-X-C motif) ligand 1 | Mus musculus |
| 2 | Furthermore, in CXCL1-transfected muscles, muscular ex vivo fatty acid oxidation was significantly enhanced compared with control muscles (chow fed: 2.2-fold, P < 0.05; high-fat fed: 2-fold, P < 0.05) and also showed increased expression levels of major fatty acid oxidation genes (CD36, CPT I, and HADH). | Fatty Acids | chemokine (C-X-C motif) ligand 1 | Mus musculus |
| 3 | Furthermore, in CXCL1-transfected muscles, muscular ex vivo fatty acid oxidation was significantly enhanced compared with control muscles (chow fed: 2.2-fold, P < 0.05; high-fat fed: 2-fold, P < 0.05) and also showed increased expression levels of major fatty acid oxidation genes (CD36, CPT I, and HADH). | Fatty Acids | chemokine (C-X-C motif) ligand 1 | Mus musculus |
| 4 | In conclusion, our data show that overexpression of CXCL1 within a physiological range attenuates diet-induced obesity, likely mediated through a CXCL1-induced improvement of fatty acid oxidation and oxidative capacity in skeletal muscle tissue. | Fatty Acids | chemokine (C-X-C motif) ligand 1 | Mus musculus |
| 5 | In conclusion, our data show that overexpression of CXCL1 within a physiological range attenuates diet-induced obesity, likely mediated through a CXCL1-induced improvement of fatty acid oxidation and oxidative capacity in skeletal muscle tissue. | Fatty Acids | chemokine (C-X-C motif) ligand 1 | Mus musculus |