Pub. Date : 2012 Aug
PMID : 22228482
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Scutellarin inhibits cytochrome P450 isoenzyme 1A2 (CYP1A2) in rats. | scutellarin | cytochrome P450, family 1, subfamily a, polypeptide 2 | Rattus norvegicus |
| 2 | Scutellarin inhibits cytochrome P450 isoenzyme 1A2 (CYP1A2) in rats. | scutellarin | cytochrome P450, family 1, subfamily a, polypeptide 2 | Rattus norvegicus |
| 3 | The present study investigated the in vitro and in vivo effects of scutellarin on cytochrome P450 1A2 (CYP 1A2) metabolism. | scutellarin | cytochrome P450, family 1, subfamily a, polypeptide 2 | Rattus norvegicus |
| 4 | The present study investigated the in vitro and in vivo effects of scutellarin on cytochrome P450 1A2 (CYP 1A2) metabolism. | scutellarin | cytochrome P450, family 1, subfamily a, polypeptide 2 | Rattus norvegicus |
| 5 | Scutellarin at 30 mg/kg also weakly inhibited CYP1A2 activity, in accordance with our in vitro study. | scutellarin | cytochrome P450, family 1, subfamily a, polypeptide 2 | Rattus norvegicus |
| 6 | Thus, the results indicate that CYP1A2 is inhibited directly, but weakly, by scutellarin in vivo, and provide useful information on the safe and effective use of scutellarin in clinical practice. | scutellarin | cytochrome P450, family 1, subfamily a, polypeptide 2 | Rattus norvegicus |
| 7 | Thus, the results indicate that CYP1A2 is inhibited directly, but weakly, by scutellarin in vivo, and provide useful information on the safe and effective use of scutellarin in clinical practice. | scutellarin | cytochrome P450, family 1, subfamily a, polypeptide 2 | Rattus norvegicus |