Title : HBD-1 and hBD-2 expression in HaCaT keratinocytes stimulated with nicotine.

Pub. Date : 2012 Jun

PMID : 22209221






4 Functional Relationships(s)
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1 RESULTS: Pretreatment with nicotine caused a significant 2.5-fold inhibition of TNF-alpha-stimulated hBD-2 mRNA expression compared to TNF-alpha alone (p = 0.004). Nicotine tumor necrosis factor Homo sapiens
2 RESULTS: Pretreatment with nicotine caused a significant 2.5-fold inhibition of TNF-alpha-stimulated hBD-2 mRNA expression compared to TNF-alpha alone (p = 0.004). Nicotine tumor necrosis factor Homo sapiens
3 Simultaneous treatment with TNF-alpha and nicotine caused a significant 2-fold inhibition of hBD-2 mRNA compared to TNF-alpha alone (p = 0.041). Nicotine tumor necrosis factor Homo sapiens
4 CONCLUSION: The present results suggest that the pre-exposition to nicotine seems to reduce a stimulating effect of TNF-alpha on the gene expression of hBD-2. Nicotine tumor necrosis factor Homo sapiens