Title : Acute insulin resistance following surgical trauma in rats.

Pub. Date : 2012 Jun

PMID : 22187297






1 Functional Relationships(s)
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1 Trauma induced Ser phosphorylation instead of Tyr phosphorylation eliminated the ability of IRS-1 to activate downstream effector molecules such as PKB/Akt and resulted in severe impairment of insulin signal transduction and glucose transport in skeletal muscle. Tyrosine insulin receptor substrate 1 Rattus norvegicus