Title : Assessment of the role for Rho family GTPases in NADPH oxidase activation.

Pub. Date : 2012

PMID : 22144277






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Rac in the GTP-bound form directly binds to the oxidase activator p67( phox ), which in turn interacts with Nox2, leading to superoxide production. Superoxides CD33 molecule Homo sapiens
2 On the other hand, in the presence of either p67( phox ) or Noxa1, Rac facilitates superoxide production by Nox3, which is responsible in the inner ear for formation of otoconia, tiny mineralized structures that are required for sensing balance and gravity. Superoxides CD33 molecule Homo sapiens