Title : Brain penetration of the OAB drug trospium chloride is not increased in aged mice.

Pub. Date : 2013 Feb

PMID : 22120415






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1 CONCLUSION: Based on our in vivo data in a mouse model, we conclude that trospium chloride permeation across the BBB is not increased in ageing per se, and therefore, the occurrence of adverse CNS drug effects is also not expected to increase with ageing. trospium chloride ALMS1, centrosome and basal body associated Mus musculus