Title : Brain penetration of the OAB drug trospium chloride is not increased in aged mice.

Pub. Date : 2013 Feb

PMID : 22120415






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1 METHODS: Trospium chloride at 1 mg/kg was intravenously administered to adult, middle-aged, and aged mice at 6, 12, and 24 months of age, respectively, and the absolute drug concentrations in the brain were analysed after 2 h. Furthermore, mRNA expression levels of relevant markers of blood-brain barrier integrity (occludin, claudin-5, and the drug efflux carrier P-glycoprotein) were analysed in brain samples from adult and aged mice. trospium chloride claudin 5 Mus musculus