Pub. Date : 2012 Mar
PMID : 22076107
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Some CYP1A inducers are known to exert hepatocellular tumor-promoting activities in rodents, and reactive oxygen species (ROS) produced by CYP1A1 induction via a metabolism of FLU is probably involved in the liver tumor promotion. | Flutamide | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |
| 2 | The results of microarray and real-time RT-PCR revealed that phase 1 drug-metabolizing enzymes such as CYP1A1, Ugt1a61 and Nqo1 and phase II drug-metabolizing enzymes such as Yc2, Akr1b7, Akr1b8, Akr1b10, Aldh1a1, Gpx2 and Me1 were up-regulated in rats treated with FLU. | Flutamide | cytochrome P450, family 1, subfamily a, polypeptide 1 | Rattus norvegicus |