Title : CYP2F2-generated metabolites, not styrene oxide, are a key event mediating the mode of action of styrene-induced mouse lung tumors.

Pub. Date : 2012 Feb

PMID : 22041433






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Importantly, the human isoform of CYP2F, CYP2F1, is expressed at much lower levels and likely does not catalyze significant styrene metabolism, supporting the hypothesis that styrene-induced mouse lung tumors may not quantitatively, or possibly qualitatively, predict lung tumor potential in humans. Styrene cytochrome P450 family 2 subfamily F member 1 Homo sapiens