Pub. Date : 2011
PMID : 22016822
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we investigated the effects of the ZD6474, a small molecule RET-inhibitor, on RET/beta-catenin interaction. | vandetanib | catenin beta 1 | Homo sapiens |
| 2 | Surprisingly, RET and beta-catenin co-immunoprecipitated in both ZD6474-treated and untreated TPC1 cells, suggesting that RET/beta-catenin interaction might not be affected by RET kinase inactivation. | vandetanib | catenin beta 1 | Homo sapiens |
| 3 | Surprisingly, RET and beta-catenin co-immunoprecipitated in both ZD6474-treated and untreated TPC1 cells, suggesting that RET/beta-catenin interaction might not be affected by RET kinase inactivation. | vandetanib | catenin beta 1 | Homo sapiens |
| 4 | In conclusion, ZD6474, by inhibiting RET kinase, down-modulates beta-catenin pathway leading its recruitment to the membrane by E-cadherin. | vandetanib | catenin beta 1 | Homo sapiens |