Title : Caffeine modulates phosphorylation of insulin receptor substrate-1 and impairs insulin signal transduction in rat skeletal muscle.

Pub. Date : 2011 Dec

PMID : 21940847






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Blockade of IKK/IRS-1 Ser(307) by caffeic acid ameliorated the caffeine-induced downregulation of IRS-1 Tyr(612) phosphorylation and 3MG transport. Tyrosine insulin receptor substrate 1 Rattus norvegicus
2 Blockade of IKK/IRS-1 Ser(307) by caffeic acid ameliorated the caffeine-induced downregulation of IRS-1 Tyr(612) phosphorylation and 3MG transport. Tyrosine insulin receptor substrate 1 Rattus norvegicus
3 Intravenous injection of caffeine at a physiological dose (5 mg/kg) in rats inhibited the phosphorylation of insulin-stimulated IRS-1 Tyr(612) and Akt Ser(473) in epitrochlearis muscle. Tyrosine insulin receptor substrate 1 Rattus norvegicus