Pub. Date : 2011
PMID : 21897055
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of efonidipine on TGF-beta1-induced cardiac fibrosis through Smad2-dependent pathway in rat cardiac fibroblasts. | efonidipine | SMAD family member 2 | Rattus norvegicus |
| 2 | TGF-beta1 (5 ng/mL) significantly increased Smad2 phosphorylation and [(3)H]-leucine incorporation, which were attenuated by pretreatment with efonidipine (10 microM). | efonidipine | SMAD family member 2 | Rattus norvegicus |
| 3 | These data suggest that efonidipine elicits inhibitory effects on TGF-beta1- and Smad2-dependent protein synthesis through both T-type and L-type calcium channel-blocking actions in cardiac fibroblasts. | efonidipine | SMAD family member 2 | Rattus norvegicus |