Title : cGMP inhibits TGF-beta signaling by sequestering Smad3 with cytosolic beta2-tubulin in pulmonary artery smooth muscle cells.

Pub. Date : 2011 Oct

PMID : 21868450






1 Functional Relationships(s)
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1 In addition, disruption of beta2-tubulin with the microtubule depolymerizers nocodazole and colchicine promoted Smad3 dissociation from beta2-tubulin, increased both TGF-beta1-induced Smad3 nuclear translocation and PAI-1 mRNA expression, and abolished the inhibitory effects of cGMP on these processes. Nocodazole transforming growth factor beta 1 Homo sapiens