Pub. Date : 2011 Jul 27
PMID : 21796211
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In vitro, 7alpha,25-OHC stimulated the migration of EBI2-expressing mouse B and T cells with half-maximum effective concentration values around 500 pM, but had no effect on EBI2-deficient cells. | 25-hydroxycholesterol | G protein-coupled receptor 183 | Mus musculus |
| 2 | In vivo, EBI2-deficient B cells or normal B cells desensitized by 7alpha,25-OHC pre-treatment showed reduced homing to follicular areas of the spleen. | 25-hydroxycholesterol | G protein-coupled receptor 183 | Mus musculus |
| 3 | Blocking the synthesis of 7alpha,25-OHC in vivo with clotrimazole, a CYP7B1 inhibitor, reduced the content of 7alpha,25-OHC in the mouse spleen and promoted the migration of adoptively transferred pre-activated B cells to the T/B boundary (the boundary between the T-zone and B-zone in the spleen follicle), mimicking the phenotype of pre-activated B cells from EBI2-deficient mice. | 25-hydroxycholesterol | G protein-coupled receptor 183 | Mus musculus |