Title : Chronic nicotine administration impairs activation of cyclic AMP-response element binding protein and survival of newborn cells in the dentate gyrus.

Pub. Date : 2012 Feb 10

PMID : 21740234






6 Functional Relationships(s)
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1 Chronic nicotine administration impairs activation of cyclic AMP-response element binding protein and survival of newborn cells in the dentate gyrus. Nicotine cAMP responsive element binding protein 1 Rattus norvegicus
2 Here, we demonstrate that chronic nicotine administration in adult rats inactivates the cyclic AMP-response element binding protein (CREB), a transcription factor that regulates neurogenesis and other plasticity-related processes necessary for learning and memory. Nicotine cAMP responsive element binding protein 1 Rattus norvegicus
3 Here, we demonstrate that chronic nicotine administration in adult rats inactivates the cyclic AMP-response element binding protein (CREB), a transcription factor that regulates neurogenesis and other plasticity-related processes necessary for learning and memory. Nicotine cAMP responsive element binding protein 1 Rattus norvegicus
4 Additionally, we found that retroviral-mediated expression of a constitutively active CREB in the dentate gyrus rescues survival of newborn cells and reverses the nicotine-induced decline in the number of mature granule neurons. Nicotine cAMP responsive element binding protein 1 Rattus norvegicus
5 Prolonged nicotine exposure also compromises CREB activation and reduces the viability of progenitor cells in vitro, thereby suggesting that nicotine may exert its adverse effects directly on immature cells in vivo. Nicotine cAMP responsive element binding protein 1 Rattus norvegicus
6 Taken together, these data demonstrate that inhibition of CREB activation is responsible for the nicotine-induced impairment of hippocampal plasticity. Nicotine cAMP responsive element binding protein 1 Rattus norvegicus