Title : Catecholamines mediate nicotine-induced adrenocorticotropin secretion via alpha-adrenergic receptors.

Pub. Date : 1990 Oct

PMID : 2169395






6 Functional Relationships(s)
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1 Previous studies determined that iv nicotine stimulates ACTH secretion by acting on sites accessible from the fourth ventricle (IV), rather than directly on CRF-containing neurons in the hypothalamus. Nicotine proopiomelanocortin Homo sapiens
2 Therefore, these studies investigated the role of catecholamines in nicotine-stimulated ACTH secretion. Nicotine proopiomelanocortin Homo sapiens
3 Experiments with the catecholaminergic neurotoxin, 6-hydroxydopamine, demonstrate that the ACTH response to nicotine delivered iv (0.03 or 0.05 mg/kg body wt) or instilled into the IV (1 or 2.5 micrograms) was significantly reduced in lesioned animals (P less than 0.01). Nicotine proopiomelanocortin Homo sapiens
4 Selective inhibitors of epinephrine synthesis, SKF 64139 and 2,3-dichloro-alpha-methylbenzylamine (DCMB), significantly reduced (P less than 0.01) the ACTH response to 0.05 mg/kg body wt nicotine iv, without affecting median eminence CRF content. Nicotine proopiomelanocortin Homo sapiens
5 To determine whether alpha 2 receptors are indeed involved in the ACTH response to nicotine, yohimbine, an alpha 2 antagonist, was injected into the third ventricle before nicotine injection into the IV. Nicotine proopiomelanocortin Homo sapiens
6 Thus, both alpha 1 and alpha 2 receptors are involved in mediating the ACTH response to nicotine. Nicotine proopiomelanocortin Homo sapiens