Pub. Date : 2011
PMID : 21625550
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Lycopene inhibits NF-kB-mediated IL-8 expression and changes redox and PPARgamma signalling in cigarette smoke-stimulated macrophages. | Lycopene | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 2 | The aim of this study was to investigate the role of lycopene on the production of the pro-inflammatory cytokine IL-8 induced by cigarette smoke and the possible mechanisms implicated. | Lycopene | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 3 | Lycopene pre-treatment resulted in a significant inhibition of CSE-induced IL-8 expression at both mRNA and protein levels. | Lycopene | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 4 | Taken together, our data indicate that lycopene prevented CSE-induced IL-8 production through a mechanism involving an inactivation of NF-kB. | Lycopene | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 5 | The ability of lycopene in inhibiting IL-8 production, NF-kB/p65 nuclear translocation, and redox signalling and in increasing PPARgamma expression was also found in isolated rat alveolar macrophages exposed to CSE. | Lycopene | C-X-C motif chemokine ligand 8 | Homo sapiens |