Title : Overnight ACTH-cortisol dose responsiveness: comparison with 24-h data, metyrapone administration and insulin-tolerance test in healthy adults.

Pub. Date : 2011 Nov

PMID : 21609353






2 Functional Relationships(s)
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1 Compared with placebo, metyrapone reduced ACTH efficacy from 11 (6 2-62) to 2 8 (1 5-4 5) nmol/l/min for cortisol (n = 9, P < 0 001), while increasing ACTH efficacy for 11-desoxycortisol from 2 3 (0 9-2 9) to 99 (70-218) nmol/l/min (n = 6, P < 0 01), thus affirming face validity. Metyrapone proopiomelanocortin Homo sapiens
2 Compared with placebo, metyrapone reduced ACTH efficacy from 11 (6 2-62) to 2 8 (1 5-4 5) nmol/l/min for cortisol (n = 9, P < 0 001), while increasing ACTH efficacy for 11-desoxycortisol from 2 3 (0 9-2 9) to 99 (70-218) nmol/l/min (n = 6, P < 0 01), thus affirming face validity. Metyrapone proopiomelanocortin Homo sapiens