Title : Tristetraprolin mediates anti-inflammatory effects of nicotine in lipopolysaccharide-stimulated macrophages.

Pub. Date : 2011 Jul 15

PMID : 21606497






6 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Nicotine inhibits the release of TNF-alpha from macrophage through activation of STAT3. Nicotine signal transducer and activator of transcription 3 Homo sapiens
2 Nicotine induced activation of STAT3 enhanced STAT3 binding to the TTP promoter, increased TTP promoter activity, and increased TTP expression resulting in the suppression of LPS-stimulated TNF-alpha production. Nicotine signal transducer and activator of transcription 3 Homo sapiens
3 Nicotine induced activation of STAT3 enhanced STAT3 binding to the TTP promoter, increased TTP promoter activity, and increased TTP expression resulting in the suppression of LPS-stimulated TNF-alpha production. Nicotine signal transducer and activator of transcription 3 Homo sapiens
4 Overexpression of a dominant negative mutant of STAT3 (R382W) or down-regulation of STAT3 by siRNA abolished nicotine-induced TTP expression and suppression of LPS-stimulated TNF-alpha production. Nicotine signal transducer and activator of transcription 3 Homo sapiens
5 Overexpression of a dominant negative mutant of STAT3 (R382W) or down-regulation of STAT3 by siRNA abolished nicotine-induced TTP expression and suppression of LPS-stimulated TNF-alpha production. Nicotine signal transducer and activator of transcription 3 Homo sapiens
6 In this experiment, we are reporting for the first time the involvement of TTP in the cholinergic anti-inflammatory cascade consisting of nicotine-STAT3-TTP-dampening inflammation. Nicotine signal transducer and activator of transcription 3 Homo sapiens