Title : [Adiponectin decreases insulin receptor substrate-1 phosphorylation in the liver of OLETF rats possibly through nuclear factor-κB signaling pathway].

Pub. Date : 2011 May

PMID : 21602124






1 Functional Relationships(s)
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1 CONCLUSION: APN may decrease tyrosine phosphorylation of IRS-1 via the IKK/NFkappaB pathway and inhibit insulin signaling pathway in the liver, which contributes to hyperlipidemia, hyperglycemia and development of type 2 diabetes. Tyrosine insulin receptor substrate 1 Rattus norvegicus