Pub. Date : 2011 Jul 1
PMID : 21550982
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we report that arsenite binds to both CCHC DNA-binding zinc fingers of the DNA repair protein PARP-1 (poly(ADP-ribose) polymerase-1). | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 2 | Here, we report that arsenite binds to both CCHC DNA-binding zinc fingers of the DNA repair protein PARP-1 (poly(ADP-ribose) polymerase-1). | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 3 | MALDI-TOF-MS analysis of peptides harboring site-directed substitutions of cysteine with histidine residues within the PARP-1 zinc finger revealed that arsenite bound to peptides containing three or four cysteine residues, but not to peptides with two cysteines, demonstrating arsenite binding selectivity. | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 4 | To investigate the impact of arsenite on PARP-1 zinc finger function, we measured the zinc content and DNA-binding capacity of PARP-1 immunoprecipitated from arsenite-exposed cells. | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 5 | These findings demonstrate that PARP-1 is a direct molecular target of arsenite and that arsenite interacts selectively with zinc finger motifs containing three or more cysteine residues. | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 6 | These findings demonstrate that PARP-1 is a direct molecular target of arsenite and that arsenite interacts selectively with zinc finger motifs containing three or more cysteine residues. | arsenite | poly(ADP-ribose) polymerase 1 | Homo sapiens |