Title : Removal of H₂O₂ and generation of superoxide radical: role of cytochrome c and NADH.

Pub. Date : 2011 Jul 1

PMID : 21545835






6 Functional Relationships(s)
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1 Studies were performed to understand the related mechanisms of radical generation and NADH oxidation by Fe3+cyt c in the presence of H2O2. NAD cytochrome c, somatic Homo sapiens
2 The amount of superoxide radical adduct formed from the oxidation of NADH by the peroxidase activity of Fe3+cyt c increased with NADH and H2O2 concentration. NAD cytochrome c, somatic Homo sapiens
3 The amount of superoxide radical adduct formed from the oxidation of NADH by the peroxidase activity of Fe3+cyt c increased with NADH and H2O2 concentration. NAD cytochrome c, somatic Homo sapiens
4 From these results, we propose a mechanism in which the peroxidase activity of Fe3+cyt c oxidizes NADH to NAD( ), which in turn donates an electron to O2, resulting in superoxide radical formation. NAD cytochrome c, somatic Homo sapiens
5 From these results, we propose a mechanism in which the peroxidase activity of Fe3+cyt c oxidizes NADH to NAD( ), which in turn donates an electron to O2, resulting in superoxide radical formation. NAD cytochrome c, somatic Homo sapiens
6 A UV-visible spectroscopic study shows that Fe3+cyt c is reduced in the presence of both NADH and H2O2. NAD cytochrome c, somatic Homo sapiens