Title : Interleukin-12 treatment down-regulates STAT4 and induces apoptosis with increasing ROS production in human natural killer cells.

Pub. Date : 2011 Jul

PMID : 21543583

1 Functional Relationships(s)
Compound Name
Protein Name
1 IL-12 treatment induces NK cell activation as well as levels of ROS, but prolonged IL-12 treatment causes ROS accumulation, which in turn, results in the loss of Deltapsi(m), the release of cytochrome c, and the activation of caspase-3, resulting in NK cell apoptosis. ros caspase 3 Homo sapiens