Title : Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations.

Pub. Date : 2011 Jun 15

PMID : 21531761






3 Functional Relationships(s)
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1 The antihelminth compound niclosamide downregulates components of the Wnt pathway, specifically Dishevelled-2 (Dvl2) expression, resulting in diminished downstream beta-catenin signaling. Niclosamide dishevelled segment polarity protein 2 Homo sapiens
2 The antihelminth compound niclosamide downregulates components of the Wnt pathway, specifically Dishevelled-2 (Dvl2) expression, resulting in diminished downstream beta-catenin signaling. Niclosamide dishevelled segment polarity protein 2 Homo sapiens
3 We found that niclosamide inhibited Wnt/beta-catenin pathway activation, downregulated Dvl2, decreased downstream beta-catenin signaling, and exerted antiproliferative effects in human colon cancer cell lines and CRC cells isolated by surgical resection of metastatic disease, regardless of mutations in APC. Niclosamide dishevelled segment polarity protein 2 Homo sapiens