Title : [NB4 cell apoptosis induced by bortezomib combined with As(2)O(3) and its mechanism].

Pub. Date : 2011 Apr

PMID : 21518486






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The results showed that the bortezomib combined with As(2)O(3) could induce significant apoptosis of NB4 cells and activation of caspase 3 and caspase 9, but As(2)O(3) (0.5 micromol/L) alone could not cause marked activation of caspase cascade and apoptosis of NB4 cells. Arsenic Trioxide caspase 3 Homo sapiens
2 The expression level of NOXA in NB4 cells induced by bortezomib combined with As(2)O(3) was up-regulated; the activation level of caspase-3 and apoptotic rate of NB4 cells treated by bortezomib combined with As(2)O(3) decreased after specifically silencing the NOXA gene. Arsenic Trioxide caspase 3 Homo sapiens