Title : Aripiprazole inhibits superoxide generation from phorbol-myristate-acetate (PMA)-stimulated microglia in vitro: implication for antioxidative psychotropic actions via microglia.

Pub. Date : 2011 Jul

PMID : 21497059






1 Functional Relationships(s)
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1 Aripiprazole proved to inhibit the O(2)(-) generation through the cascade of protein kinase C (PKC) activation, intracellular Ca(2+) regulation and NADPH oxidase activation via cytosolic p47(phox) translocation to the plasma/phagosomal membranes. Superoxides pleckstrin Homo sapiens