Title : IL-1β stimulates IL-8 production, including prostaglandin E2 receptor EP4-triggered pathways, in synoviocyte MH7A cells.

Pub. Date : 2009 May-Jun

PMID : 21475837






3 Functional Relationships(s)
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1 PGE2 alone has no effect on IL-8 production, but in cells pretreated with IL-1beta it markedly enhances IL-8 production. Dinoprostone C-X-C motif chemokine ligand 8 Homo sapiens
2 Moreover, a stimulatory effect of PGE2 on IL-8 production in the synoviocyte MH7A cells was observed. Dinoprostone C-X-C motif chemokine ligand 8 Homo sapiens
3 These results indicate that, in the synovial tissues of patients with rheumatoid arthritis, PGE2 stimulates the release of IL-8 from the fibroblastic cells classified as present, thereby exacerbating inflammation. Dinoprostone C-X-C motif chemokine ligand 8 Homo sapiens