Title : Interleukin-8 overexpression in astrocytomas is induced by prostaglandin E2 and is associated with the transcription factors CCAAT/enhancer-binding protein-β and CCAAT/enhancer-binding homologous protein.

Pub. Date : 2011 Sep

PMID : 21471847






13 Functional Relationships(s)
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1 Interleukin-8 overexpression in astrocytomas is induced by prostaglandin E2 and is associated with the transcription factors CCAAT/enhancer-binding protein-beta and CCAAT/enhancer-binding homologous protein. Dinoprostone C-X-C motif chemokine ligand 8 Homo sapiens
2 OBJECTIVE: To evaluate (1) the correlation between the mRNA levels of IL-8, mPGES-1, and the main transcription factors (TFs) activating the IL-8 promoter in human brain tumors of different grades; (2) the role of prostaglandin E2 (PGE2) on IL-8 activation and the expression of these TFs in tumor-derived cells; and (3) the biological impact of PGE2 treatment and mPGES-1 silencing on IL-8 synthesis and tumorigenesis. Dinoprostone C-X-C motif chemokine ligand 8 Homo sapiens
3 OBJECTIVE: To evaluate (1) the correlation between the mRNA levels of IL-8, mPGES-1, and the main transcription factors (TFs) activating the IL-8 promoter in human brain tumors of different grades; (2) the role of prostaglandin E2 (PGE2) on IL-8 activation and the expression of these TFs in tumor-derived cells; and (3) the biological impact of PGE2 treatment and mPGES-1 silencing on IL-8 synthesis and tumorigenesis. Dinoprostone C-X-C motif chemokine ligand 8 Homo sapiens
4 OBJECTIVE: To evaluate (1) the correlation between the mRNA levels of IL-8, mPGES-1, and the main transcription factors (TFs) activating the IL-8 promoter in human brain tumors of different grades; (2) the role of prostaglandin E2 (PGE2) on IL-8 activation and the expression of these TFs in tumor-derived cells; and (3) the biological impact of PGE2 treatment and mPGES-1 silencing on IL-8 synthesis and tumorigenesis. Dinoprostone C-X-C motif chemokine ligand 8 Homo sapiens
5 OBJECTIVE: To evaluate (1) the correlation between the mRNA levels of IL-8, mPGES-1, and the main transcription factors (TFs) activating the IL-8 promoter in human brain tumors of different grades; (2) the role of prostaglandin E2 (PGE2) on IL-8 activation and the expression of these TFs in tumor-derived cells; and (3) the biological impact of PGE2 treatment and mPGES-1 silencing on IL-8 synthesis and tumorigenesis. Dinoprostone C-X-C motif chemokine ligand 8 Homo sapiens
6 OBJECTIVE: To evaluate (1) the correlation between the mRNA levels of IL-8, mPGES-1, and the main transcription factors (TFs) activating the IL-8 promoter in human brain tumors of different grades; (2) the role of prostaglandin E2 (PGE2) on IL-8 activation and the expression of these TFs in tumor-derived cells; and (3) the biological impact of PGE2 treatment and mPGES-1 silencing on IL-8 synthesis and tumorigenesis. Dinoprostone C-X-C motif chemokine ligand 8 Homo sapiens
7 OBJECTIVE: To evaluate (1) the correlation between the mRNA levels of IL-8, mPGES-1, and the main transcription factors (TFs) activating the IL-8 promoter in human brain tumors of different grades; (2) the role of prostaglandin E2 (PGE2) on IL-8 activation and the expression of these TFs in tumor-derived cells; and (3) the biological impact of PGE2 treatment and mPGES-1 silencing on IL-8 synthesis and tumorigenesis. Dinoprostone C-X-C motif chemokine ligand 8 Homo sapiens
8 OBJECTIVE: To evaluate (1) the correlation between the mRNA levels of IL-8, mPGES-1, and the main transcription factors (TFs) activating the IL-8 promoter in human brain tumors of different grades; (2) the role of prostaglandin E2 (PGE2) on IL-8 activation and the expression of these TFs in tumor-derived cells; and (3) the biological impact of PGE2 treatment and mPGES-1 silencing on IL-8 synthesis and tumorigenesis. Dinoprostone C-X-C motif chemokine ligand 8 Homo sapiens
9 OBJECTIVE: To evaluate (1) the correlation between the mRNA levels of IL-8, mPGES-1, and the main transcription factors (TFs) activating the IL-8 promoter in human brain tumors of different grades; (2) the role of prostaglandin E2 (PGE2) on IL-8 activation and the expression of these TFs in tumor-derived cells; and (3) the biological impact of PGE2 treatment and mPGES-1 silencing on IL-8 synthesis and tumorigenesis. Dinoprostone C-X-C motif chemokine ligand 8 Homo sapiens
10 OBJECTIVE: To evaluate (1) the correlation between the mRNA levels of IL-8, mPGES-1, and the main transcription factors (TFs) activating the IL-8 promoter in human brain tumors of different grades; (2) the role of prostaglandin E2 (PGE2) on IL-8 activation and the expression of these TFs in tumor-derived cells; and (3) the biological impact of PGE2 treatment and mPGES-1 silencing on IL-8 synthesis and tumorigenesis. Dinoprostone C-X-C motif chemokine ligand 8 Homo sapiens
11 PGE2-treated astroglioma cells showed a marked upregulation of IL-8, C/EBP-beta, and CHOP, as well as increased proliferation and decreased apoptosis compared with untreated cells. Dinoprostone C-X-C motif chemokine ligand 8 Homo sapiens
12 CONCLUSION: (1) PGE2 is responsible for IL-8 overexpression, independently of the malignancy grade, in astrogliomas only. Dinoprostone C-X-C motif chemokine ligand 8 Homo sapiens
13 (2) C/EBP-beta and CHOP may be involved in mediating PGE2-induced IL-8 activation in these tumors. Dinoprostone C-X-C motif chemokine ligand 8 Homo sapiens