Title : Peroxisome proliferator-activated receptor-α activation promotes macrophage reverse cholesterol transport through a liver X receptor-dependent pathway.

Pub. Date : 2011 Jun

PMID : 21441141






3 Functional Relationships(s)
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1 METHODS AND RESULTS: We demonstrated that a specific potent PPARalpha agonist GW7647 inhibited atherosclerosis and promoted macrophage RCT in hypercholesterolemic mice expressing the human apolipoprotein A-I (apoA-I) gene. GW 7647 peroxisome proliferator activated receptor alpha Mus musculus
2 We compared the effect of GW7647 on RCT in human apoA-I transgenic (hA-ITg) mice with wild-type mice and showed that the PPARalpha agonist promoted RCT in hA-ITg mice to a much greater extent than in wild-type mice, indicating that human apoA-I expression is important for PPARalpha-induced RCT. GW 7647 peroxisome proliferator activated receptor alpha Mus musculus
3 Primary murine macrophages lacking PPARalpha or LXR abolished the ability of GW7647 to promote RCT in hA-ITg mice. GW 7647 peroxisome proliferator activated receptor alpha Mus musculus