Title : The environmental obesogen tributyltin chloride acts via peroxisome proliferator activated receptor gamma to induce adipogenesis in murine 3T3-L1 preadipocytes.

Pub. Date : 2011 Oct

PMID : 21397693






5 Functional Relationships(s)
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1 The environmental obesogen tributyltin chloride acts via peroxisome proliferator activated receptor gamma to induce adipogenesis in murine 3T3-L1 preadipocytes. tributyltin peroxisome proliferator activated receptor gamma Mus musculus
2 While it is known that TBT acts through peroxisome proliferator activated receptor gamma to induce adipogenesis in MSCs, the data in 3T3-L1 preadipocytes are controversial. tributyltin peroxisome proliferator activated receptor gamma Mus musculus
3 Here we show that TBT can activate the RXR-PPARgamma heterodimer even in the presence of the PPARgamma antagonist GW9662. tributyltin peroxisome proliferator activated receptor gamma Mus musculus
4 Here we show that TBT can activate the RXR-PPARgamma heterodimer even in the presence of the PPARgamma antagonist GW9662. tributyltin peroxisome proliferator activated receptor gamma Mus musculus
5 When the culture conditions are adjusted to compensate for the short half-life of GW9662, we found that TBT induces adipogenesis, triglyceride storage and the expression of adipogenic marker genes in 3T3-L1 cells in a PPARgamma-dependent manner. tributyltin peroxisome proliferator activated receptor gamma Mus musculus