Title : Comparison of characteristics of natural autoantibodies against myeloperoxidase and anti-myeloperoxidase autoantibodies from patients with microscopic polyangiitis.

Pub. Date : 2011 Jul

PMID : 21372002






14 Functional Relationships(s)
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1 In the current study, the immune characteristics of MPO-NAA and MPO-ANCA were examined and compared with the aim to investigate the pathogenesis of MPO-ANCA. 1-naphthaleneacetic acid myeloperoxidase Homo sapiens
2 The MPO-NAA-induced production of reactive oxygen species was assessed using oxidation of dihydrorhodamine (DHR) to rhodamine. 1-naphthaleneacetic acid myeloperoxidase Homo sapiens
3 RESULTS: MPO-NAA recognized epitope(s) in the heavy chains of MPO with conformation-dependent structure, the same as MPO-ANCA. 1-naphthaleneacetic acid myeloperoxidase Homo sapiens
4 RESULTS: MPO-NAA recognized epitope(s) in the heavy chains of MPO with conformation-dependent structure, the same as MPO-ANCA. 1-naphthaleneacetic acid myeloperoxidase Homo sapiens
5 RESULTS: MPO-NAA recognized epitope(s) in the heavy chains of MPO with conformation-dependent structure, the same as MPO-ANCA. 1-naphthaleneacetic acid myeloperoxidase Homo sapiens
6 The median titre of MPO-NAA was lower than that of MPO-ANCA (1 : 40 vs 1 : 4800, P < 0.001). 1-naphthaleneacetic acid myeloperoxidase Homo sapiens
7 The median avidity of MPO-NAA was lower than that of MPO-ANCA (2.2 x 10(7) vs 8.7 x 10(7)/M, P = 0.014). 1-naphthaleneacetic acid myeloperoxidase Homo sapiens
8 The IgG subclasses of MPO-NAA were mainly restricted to IgG1 (100%) and lack of IgG3. 1-naphthaleneacetic acid myeloperoxidase Homo sapiens
9 The inhibition effect on the binding between ceruloplasmin and MPO was lower for MPO-NAA than MPO-ANCA (P = 0.046). 1-naphthaleneacetic acid myeloperoxidase Homo sapiens
10 The inhibition effect on the binding between ceruloplasmin and MPO was lower for MPO-NAA than MPO-ANCA (P = 0.046). 1-naphthaleneacetic acid myeloperoxidase Homo sapiens
11 The inhibition effect on the binding between ceruloplasmin and MPO was lower for MPO-NAA than MPO-ANCA (P = 0.046). 1-naphthaleneacetic acid myeloperoxidase Homo sapiens
12 The MPO-NAA-induced respiratory burst of neutrophils was significantly weaker than that of MPO-ANCA (P = 0.036). 1-naphthaleneacetic acid myeloperoxidase Homo sapiens
13 CONCLUSION: The lower titre, lower avidity and lack of IgG3 subclass compared with MPO-ANCA may contribute to the non-pathogenic co-existence of MPO-NAA with MPO in serum. 1-naphthaleneacetic acid myeloperoxidase Homo sapiens
14 CONCLUSION: The lower titre, lower avidity and lack of IgG3 subclass compared with MPO-ANCA may contribute to the non-pathogenic co-existence of MPO-NAA with MPO in serum. 1-naphthaleneacetic acid myeloperoxidase Homo sapiens