Title : Functionality of fondaparinux (pentasaccharide) depends on clinical antithrombin levels.

Pub. Date : 2011 Apr

PMID : 21297455






6 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Fondaparinux (Arixtra) is an antithrombin (AT)-dependent synthetic inhibitor of factor Xa (FXa). Fondaparinux serpin family C member 1 Homo sapiens
2 Fondaparinux (Arixtra) is an antithrombin (AT)-dependent synthetic inhibitor of factor Xa (FXa). Fondaparinux serpin family C member 1 Homo sapiens
3 For 0.2-1.5 mug/ml fondaparinux (plasma concentrations achieved with dosages for prophylaxis and treatment of venous thromboembolism) and AT levels of 0.5 U/ml there was 20% loss of activity and with 0.25 U/ml AT there was a 45% loss of activity compared to 1 U/ml AT. Fondaparinux serpin family C member 1 Homo sapiens
4 For 0.2-1.5 mug/ml fondaparinux (plasma concentrations achieved with dosages for prophylaxis and treatment of venous thromboembolism) and AT levels of 0.5 U/ml there was 20% loss of activity and with 0.25 U/ml AT there was a 45% loss of activity compared to 1 U/ml AT. Fondaparinux serpin family C member 1 Homo sapiens
5 With AT levels below 30% of normal induced by anti-AT antibodies, there was a 60% in-vivo reduction in the antithrombotic activity of fondaparinux (ED50 75 vs. 240 mug/kg). Fondaparinux serpin family C member 1 Homo sapiens
6 With AT levels below 30% of normal induced by anti-AT antibodies, there was a 60% in-vivo reduction in the antithrombotic activity of fondaparinux (ED50 75 vs. 240 mug/kg). Fondaparinux serpin family C member 1 Homo sapiens