Title : In vitro selected RNA aptamer recognizing glutathione induces ROS mediated apoptosis in the human breast cancer cell line MCF 7.

Pub. Date : 2011 Jan-Feb

PMID : 21282976






1 Functional Relationships(s)
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1 Cultured breast cancer cells (MCF7) responded to expression of GSH aptamers by accumulating ROS and undergoing morphological transition, nuclear condensation, and DNA fragmentation, with concurrent depletion of cellular GSH and activation of caspase 3 eventually leading to apoptosis. Glutathione caspase 3 Homo sapiens