Title : Inhibition of cardiac Ca2+ release channels (RyR2) determines efficacy of class I antiarrhythmic drugs in catecholaminergic polymorphic ventricular tachycardia.

Pub. Date : 2011 Apr

PMID : 21270101






2 Functional Relationships(s)
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1 Only flecainide and propafenone inhibited RyR2 channels, with the S-enantiomer of propafenone having a significantly lower potency than R-propafenone or flecainide. Propafenone ryanodine receptor 2, cardiac Mus musculus
2 Only flecainide and propafenone inhibited RyR2 channels, with the S-enantiomer of propafenone having a significantly lower potency than R-propafenone or flecainide. Propafenone ryanodine receptor 2, cardiac Mus musculus