Title : Potentiation of NGF-induced neurite outgrowth in PC12 cells by papaverine: role played by PLC-γ, IP3 receptors.

Pub. Date : 2011 Mar 4

PMID : 21211516






1 Functional Relationships(s)
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1 Furthermore, papaverine"s potentiation of NGF-induced neurite outgrowth was also blocked by the co-administration of inositol 1,4,5-trisphosphate (IP(3)) receptor antagonists (xestospongin C and 2-aminoethoxydiphenyl borate (2-APB)) and by reduced expression of IP(3) receptor gene (i.e., itpr1 and itpr3) by siRNA. xestospongin C inositol 1,4,5-trisphosphate receptor, type 3 Rattus norvegicus